Analysis of 14-bp HLA-G polymorphism in middle-eastern women with recurrent implantation failure
نویسندگان
چکیده
منابع مشابه
the hla-g 14-bp insertion/ deletion polymorphism in recurrent spontaneous abortion among iranian women
hla-g is a non-classical hla class ib molecule with limited protein variability generated by alternative splicing. hla-g displays immunotolerant properties and hence plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. polymorphism of the hla-g gene may potentially affect the biological properties of the protein, and a ...
متن کاملThe HLA-G 14-bp Insertion/ Deletion Polymorphism in Recurrent Spontaneous Abortion among Iranian Women
HLA-G is a non-classical HLA class Ib molecule with limited protein variability generated by alternative splicing. HLA-G displays immunotolerant properties and hence plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. Polymorphism of the HLA-G gene may potentially affect the biological properties of the protein, and a 14-bp inser...
متن کاملassociation of the maternal 14-bp insertion/deletion polymorphism in the histocompatibility leukocyte antigen g gene with recurrent implantation failure
background: implantation failure of blastocyst is one of the main reasons of failure to become pregnancy following use of assisted reproductive techniques. hla-g, one of the non-classic hla subtypes, seems to have a vital role in neutralizing of mother immune system. according to importance of ins/del polymorphism of hla-g in regulation of hla-g expression, it seems that this polymorphism has a...
متن کاملAssociation of the maternal 14-bp insertion/deletion polymorphism in the histocompatibility leukocyte antigen G gene with recurrent implantation failure
BACKGROUND Implantation failure of blastocyst is one of the main reasons of failure to become pregnancy following use of Assisted Reproductive Techniques. HLA-G, one of the non-classic HLA subtypes, seems to have a vital role in neutralizing of mother immune system. According to importance of ins/del polymorphism of HLA-G in regulation of HLA-G expression, it seems that this polymorphism has an...
متن کاملGenetic association between the HLA-G 14-bp insertion/deletion polymorphism and the recurrent spontaneous abortions in Saudi Arabian women.
The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localized at the 3' untranslated region was ass...
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ژورنال
عنوان ژورنال: International Journal of Reproduction, Contraception, Obstetrics and Gynecology
سال: 2020
ISSN: 2320-1789,2320-1770
DOI: 10.18203/2320-1770.ijrcog20205215